Kirsi Bourget Selected Research

Palmitic Acid (Hexadecanoic Acid)

1/2022	The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism.
1/2020	Carbon Chain Length Modulates MDA-MB-231 Breast Cancer Cell Killing Mechanisms by Mitochondrially Targeted Aryl-Urea Fatty Acids.
3/2019	Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells.
1/2018	Carboxylate Analogues of Aryl-Urea-Substituted Fatty Acids That Target the Mitochondria in MDA-MB-231 Breast Cancer Cells to Promote Cell Death.
10/2017	A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells.

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Kirsi Bourget Research Topics

Disease

11	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2012
10	Neoplasms (Cancer) 01/2022 - 08/2012
2	Triple Negative Breast Neoplasms 01/2022 - 12/2017
1	Necrosis 01/2020
1	Leukemia 08/2013
1	Carcinoma (Carcinomatosis) 08/2013
1	Carcinogenesis 08/2012
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 09/2007

Drug/Important Bio-Agent (IBA)

8	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 09/2014
5	Palmitic Acid (Hexadecanoic Acid)IBA 01/2022 - 10/2017
3	Pharmaceutical PreparationsIBA 01/2022 - 10/2017
3	AcidsIBA 10/2021 - 09/2014
3	Urea (Carbamide)FDA LinkGeneric 01/2020 - 01/2018
3	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 08/2012
2	Cytotoxins (Cytolysins)IBA 01/2022 - 11/2017
2	Epoxy Compounds (Epoxides)IBA 10/2021 - 09/2014
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2021 - 08/2012
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	taxaneIBA 01/2022
1	Drug CombinationsIBA 01/2022
1	ixabepilone (BMS 247550)FDA Link 01/2022
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2022
1	7-aminoactinomycin DIBA 01/2020
1	CarbonIBA 01/2020
1	Annexin A5IBA 01/2020
1	p38 Mitogen-Activated Protein KinasesIBA 03/2019
1	CyclinsIBA 03/2019
1	17,18-epoxy-5,8,11,14-eicosatetraenoic acidIBA 12/2017
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 12/2017
1	CytochromesIBA 12/2017
1	Cytochrome P-450 CYP2J2 (CYP2J2)IBA 11/2017
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 11/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2017
1	Cardiolipins (Cardiolipin)IBA 10/2017
1	OxidesIBA 08/2013
1	Phosphotransferases (Kinase)IBA 08/2013
1	Sorafenib (BAY 43-9006)FDA Link 08/2013
1	Cyclin D1IBA 08/2013
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2013
1	Adenosine Triphosphate (ATP)IBA 08/2013
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 08/2012
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2012
1	Monounsaturated Fatty AcidsIBA 08/2012
1	ProstaglandinsIBA 08/2012
1	Prostaglandins EIBA 08/2012
1	Arachidonic Acid (Vitamin F)IBA 08/2012
1	Interleukin-2 Receptor alpha SubunitIBA 09/2007

Therapy/Procedure

1	Therapeutics 01/2022
1	Drug Therapy (Chemotherapy) 11/2017